منابع مشابه
Beyond the Bench: Hunting Down Fugitive Literature
Background: When multiple endpoints are of interest in evidence synthesis, a multivariate meta-analysis can jointly synthesise those endpoints and utilise their correlation. A multivariate random-effects metaanalysis must incorporate and estimate the between-study correlation (ρB). Methods: In this paper we assess maximum likelihood estimation of a general normal model and a generalised model f...
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One of the most challenging projects in the field of epigenetics is the generation of detailed functional maps of DNA methylation in different cell and tissue types in normal and disease-associated conditions. This information will help us not only understand the role of DNA methylation but also identify targets for therapeutic treatment. The completion of the various epigenome projects depends...
متن کاملHunting Down the Chimera of Multiple Disciplinarity in Conservation Science
The consensus is that both ecological and social factors are essential dimensions of conservation research and practice. However, much of the literature on multiple disciplinary collaboration focuses on the difficulties of undertaking it. This review of the challenges of conducting multiple disciplinary collaboration offers a framework for thinking about the diversity and complexity of this end...
متن کاملDown-regulation of HER2/neu expression induces apoptosis in human cancer cells that overexpress HER2/neu.
The HER2/neu oncogene is overexpressed in a significant fraction of human tumors; such overexpression is thought to play a role in the aberrant proliferation of cancer cells. The effects of HER2/neu-specific phosphorothioate antisense oligodeoxyribonucleotides on HER2/neu expression, tumor cell proliferation, and activation of apoptotic cell death pathways have been examined. Antisense treatmen...
متن کاملHunting down the Quark-gluon Plasma in Relativistic Heavy-ion Collisions
The present status of the heavy-ion program to search for quark-gluon plasma is reviewed. The goal of this program is to recreate the Big Bang in the laboratory, by generating small chunks of exploding quark-gluon plasma (“The Little Bang”). I argue that the analogues of the three pillars of Big Bang Theory (Hubble flow, microwave background radiation, and primordial nucleosynthesis) have now b...
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ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2008
ISSN: 1945-3477
DOI: 10.1038/scibx.2008.1039